Wednesday, July 5, 2017

 

Hearty News



Chiefs Announcements

 

New Faculty :

 

Kiranbir (Kebbie) Josan, MD was appointed to Clinical Assistant Professor (Cardiovascular Medicine) on April 1, 2017. Dr. Kiranbir Josan is a board-certified Cardiologist. She enjoys practicing all areas of general cardiology with a special interest in primary and secondary prevention, valvular heart disease, cardiomyopathy, atrial fibrillation and other arrhythmia management. Her current clinical and research focus includes the assessment and management of South Asian Cardiovascular Risk.

Faculty Appointments and Promotions:

 

Themistocles (Tim) Assimes, MD, PhD was promoted to Associate Professor of Medicine (Cardiovascular Medicine) on June 1, 2017.

 

 

Maurice Buchbinder, MD has been reappointed as Clinical Professor of Medicine (Cardiovascular Medicine) on July 1, 2017.

New Staff:

 

Dalia Gonzalez, Administrative Associate is supporting Drs. Hunt, Khush, Haddad and Assimes. Dalia started on May 8th.

 

 

Divya Rajmohan, MBBS, Clinical Research Coordinator is supporting Dr. Phil Yang with Cardiovascular Cell therapy Research Network (CCTRN) studies sponsored and funded by National Heart, Lung and Blood Institute studying stem cell therapy for treating heart disease. Divya started June 19th.

 

 

Alejandra Sepulveda, Clinical Research Coordinator is supporting Dr. Marco Perez with Women's Health Initiative Silent Atrial Fibrillation Recording study (WHI STAR). Alejandra started on May 15th.

New roles in the Division:

 

Rebecca (Becca) Fuhlbrigge is taking on a new role as Assistant Clinical Research Coordinator in the Stanford Center for Inherited Cardiovascular Disease (SCICD). She will be taking over clinical trial coordination from Austin Bland who is headed off to graduate school.

Reminders/Updates:

  • Thank you to faculty and especially the administrative associates that helped in coordinating the completion of the faculty reviews before the deadline
  • Another huge thank you to faculty and supervisors for getting staff evaluations in on or before May 5th
  • Upcoming faculty meetings –Tuesday, July 18th 5pm (Falk Library)
  • Annual Faculty Retreat – Saturday, September 9th 8am Location: Paul Brest Hall, Munger Conference Center
  • Faculty/Fellow Monthly Socials – upcoming dates: Friday, July 28th, Friday, August 25th, Friday, September 29th 4:30pm Falk Library
  • Annual CV Medicine Holiday Party is Saturday, December 2nd at the Crowne Plaza in Palo Alto – Save the Date!

Postdoctoral Scholar Updates and Reminders:

Please be sure that the application fits within the criteria for the appropriate rank and line for the candidate; this will be closely reviewed. Please refer to the appropriate pages on our website (short term faculty and other teaching titles) to review the criteria and required documentation. Also, please make sure that applications are submitted on time, that is, 45 days ahead of the requested start date for requests not involving visas, and 75 days ahead for requests with J-1 visas. Thank you for your attention and your patience.

Also of note: Anyone coming to Stanford who is currently a post-doc will now fall under the visiting postdoctoral scholar title, not visiting scholar. http://med.stanford.edu/ academicaffairs/short_term/ VisitingPostdoctoralScholars0. html

 

Cardiology Grand Rounds - Summer Update

Cardiology Grand Rounds is on summer break. CGR will start back up on Thursday, August 31, 2017.

Upcoming Cardiology Grand Rounds

Weekly CGR’s are on Thursdays at 8am in the Falk Library.

Our Team in the News

 

Fitness trackers accurately measure heart rate but not calories burned

A Stanford inquiry into the accuracy of seven wristband activity monitors showed that six out of seven devices measured heart rate within 5 percent. None, however, measured energy expenditure well. Millions of people wear some kind of wristband activity tracker and use the device to monitor their own exercise and health, often sharing the data with their physician. But is the data accurate?

AHA awards $2 million for cardiovascular disease research

New studies will soon get underway thanks to a pair of million-dollar research grants announced Friday by the American Heart Association. One project will look at how to match the right drug to the right patient, and the other will attempt to extend the effectiveness of high blood pressure drugs for certain patients. The two Merit Awards, each for $1 million doled out over five years, went to Joseph Wu, M.D., from Stanford University School of Medicine and Garret FitzGerald, M.D., from the University of Pennsylvania.

 

Don’t think of heart disease as inevitable, Stanford expert says

Heart disease continues to be the largest single cause of death in the United States and worldwide. But familiarity seems to breed contempt. Most American adults don’t have their cholesterol or other risk factors checked regularly, according to the Centers for Disease Control and Prevention. And when those who do see dangerously high numbers, many just sigh and vow — again — to eat better and exercise more.

Hidden heart condition threatens women

Maria Moore loves her two young children with all her heart. But just weeks after her second delivery, her heart itself was in crisis. "I felt like I just could not breathe, just something like just the heaviest thing ever crushing down on my chest," Maria remembers. But Maria says she'd also been struggling with breastfeeding and other strains of childbirth. Her chest pains weren't diagnosed as a heart attack until another episode sent her to the emergency room.

 

Early cardiology care linked to lower risk of stroke in patients with atrial fibrillation

Patients with the irregular heart rhythm known as atrial fibrillation who got early cardiology care had a reduced risk of stroke, probably because they were more likely to be prescribed anticoagulants, Stanford researchers found. The risk of stroke was significantly reduced in patients newly diagnosed with a heart condition known as atrial fibrillation who received early care from a cardiologist, according to a study by researchers at the Stanford University School of Medicine.

Researchers use long-read genome sequencing for first time in a patient

Stanford scientists have used a next-generation technology called long-read sequencing to diagnose a patient’s rare genetic condition that current technology failed to diagnose. When Ricky Ramon was 7, he went for a routine checkup. The pediatrician, who lingered over his heartbeat, sent him for a chest X-ray, which revealed a benign tumor in the top-left chamber of his heart. For Ramon, it was the beginning of a long series of medical appointments, procedures and surgeries that would span nearly two decades.

 

LIFE & STYLE When Cholesterol Drugs Cost $14,000, an Insurance Tug-of-War

Slim and athletic, Carlyn Cirrincione doesn’t look like someone who should be worried about having a heart attack. But the 22-year-old CrossFit enthusiast and avid runner has to think about the health of her heart and cholesterol levels all the time. No bacon for her. No egg yolks. Ice cream, a once-loved treat, is on the blacklist.

 

 

Upcoming Conferences and Meetings

 

July:

August:

September:

 

Funding Announcements and Upcoming Opportunities

 

NIH’s Next Generation Researchers Initiative
Dr. Francis Collins, NIH Director, announced a new policy on June 8 that eliminated the previously proposed Grant Support Index (GSI), which would have limited the amount of grant support a single investigator can have to the equivalent of three NIH R01 grants. Citing feedback and significant concerns from the scientific community and other stakeholders about the GSI-based cap, NIH is now shifting to focus on other approaches to bolster support to early- and mid-career investigators.

The multi-prong approach includes:

  • Further extending the payline for R01 equivalent applications from early stage investigators, with an aim of funding most applications that score in the top 25 percentile (or receive a score of 35 or less if not percentiled)
  • Providing additional support for mid-career investigators, defined as investigators who are within 10 years of receiving their first NIH R01 equivalent award, whose applications score in the top 25 percentile (or receive a score of 35 or less if not percentiled), by:
    • Extending the payline for those about to lose all NIH funding
    • Prioritizing funding of an additional concurrent research project grant award for particularly promising mid-career investigators currently supported by a single ongoing award
  • NIH will also place greater emphasis on current NIH funding programs aimed at early-stage and mid-career investigators, such as:
    • NIH Common Fund’s New Innovator Awards
    • National Institute of General Medicine Sciences Maximizing Investigators’ Research Award (MIRA)
    • National Institute of Dental and Craniofacial Research Sustaining Outstanding Achievement in Research (SOAR) awards
    • National Institute of Arthritis and Musculoskeletal and Skin Diseases Supplements to Advance Research (STAR) from Projects to Programs
    • Other special awards from specific institutes
  • NIH will track the impact of NIH Institute and Center funding decisions for early-stage and mid-career investigators with fundable scores, to ensure this new strategy is effectively implemented
  • NIH will encourage the development and testing of metrics that can be used to assess the impact of NIH grant support on scientific progress

Examples of recent NIH grants withdrawn prior to peer review (prepared by RMG). If you are working on a grant, please email Crystal (cbotham@stanford.edu) and Pete (ptsilva@stanford.edu).

Non-compliant Biosketches (Biosketch Templates & Instructions, see notes below)

  • Biosketch included figures and images (K08 withdrawn)
  • Biosketch included more than the allowed 4 for each contribution (F32 withdrawn)

Non-Compliant Appendix Materials (See Notice #: NOT-OD-17-035)

  • Included methodology that should be within the research strategy pages (R01 withdrawn)
  • Included published and nonpublic papers (R01 withdrawn)

Significant / Substantial Overlap (See Notice #: NOT-OD-14-074)

  • Significant scientific overlap for a duplicated submission that proceeded the referral and review process (K99 & R21 withdrawn)
  • Substantial overlap in specific aims to a funded application (K99 withdrawn)

Mismatch with Institute’s mission

  • Couldn’t find an appropriate institute for assignment (K99 withdrawn)

Have you updated your NIH Biosketch recently? Email Crystal (cbotham@stanford.edu) or Pete (ptsilva@stanford.edu) and we can help!

Things to Remember:

  • The NIH biosketch is limited to 5 pages. See Format Pages, Instructions, and Samples.
  • Personal Statement should briefly describe why you are well-suited for your role(s) in the proposed project. Relevant factors may include: aspects of your training; your previous experimental work on this specific topic or related topics; your technical expertise; your collaborators or scientific environment; and/or your past performance in this or related fields. You may cite up to four publications or research products that highlight your experience and qualifications for this project.
  • Cited research products can include, but are not limited to, audio or video products; conference proceedings such as meeting abstracts, posters, or other presentations; patents; data and research materials; databases; educational aids or curricula; instruments or equipment; models; protocols; and software or netware.
  • For each contribution (up to 5 are allowed, each limited to no longer than one half page), indicate the following:
    • the historical background that frames the scientific problem;
    • the central finding(s);
    • the influence of the finding(s) on the progress of science or the application of those finding(s) to health or technology;
    • your specific role in the described work.
    • Cite up to four publications or research products
  • To comply with the NIH Public Access Policy (FAQ), PMCID (different from PMID) is required for any manuscript that:
    • Is peer reviewed
    • And, Accepted for publication in a journal on or after April 7, 2008
    • And, arises from any director funding from NIH

If you are thinking about applying to a grant, email Crystal or Pete to learn more about the Division of Cardiovascular Medicine’s research development and proposal writing resources.

 

Important Announcements

 

Additional Funding: Cardiovascular Disease Funding Opportunities, Internal Funding Opportunities, Postdoctoral Funding Opportunities, Graduate Student.

DoD CDMRP

Peer Review Medical Research Program (48 topics including congenital heart disease, vascular malformations, women’s heart disease)

  • Clinical Trial Award (amount of funding not restricted) (pre-app: July 20)
  • Discovery Award $200K (pre-app/LOI: July 19)
  • Focused Program Award $10M (Lead PI: Associate Prof.) (pre-app: July 20)
  • Investigator-initiated Research Award $1.2-1.5M (pre-app: July 13)
  • Technology/Therapeutic Development Award $3M (Pre-app: July 13)

DoD

Stanford University

Katherine McCormick Advanced Postdoctoral Scholar Fellowship POSTDOCS
Amount of funding: $35,000
Deadline: July 2017 TBD
McCormick Fellowship

Walter V. and Idun Berry Postdoctoral Fellowship Program POSTDOCS
Amount of funding: $55,000
Deadline: July 2017 TBD
Berry Fellowship

Translational Research Applied Medicine (TRAM) Pilot Grant POSTDOCS
Amount of funding: $5K-20,000
Deadline: July 15, 2017
TRAM Pilot Grant

Stanford Cardiovascular Institute - 2017 Seed Grants
Amount of funding: $15-40K
Deadline: August 1, 2017
CVI Seed Grants

Spectrum Pilot Grants
Amount of funding: $15-50K for 1 year
Deadline: Anticipated to be end of 2017/early 2018
Spectrum Pilot Grants

California Institute for Regenerative Medicine

Discovery: Quest Awards (DISC2)
Amount of funding: $700K-1.4M
Deadline: August 15, 2017
CIRM DISC2

Partnering Opportunity for Translational Research Projects
Amount of funding: $1-4M
Deadline: August 4, 2017
CIRM TRAN

American Heart Association (AHA)

Institute for Precision Cardiovascular Medicine Grants: Uncovering New Patterns
Amount of funding: $150,000 for one year
Deadline: Aug 24, 2017
AHA

The Strategically Focused Research Vascular Disease Network
Please note: Because only ONE center application is permitted from Stanford, Dr. Tom Quertermous, the Division Chief of Cardiovascular Medicine in the Department of Medicine, will facilitate/coordinate Stanford’s response to this RFP.
Letter of Intent: Aug 1, 2017
Full proposal deadline: Sept. 26, 2017
AHA

Fondation Leduq

Transatlantic Networks of Excellence in Cardiovascular and Neurovascular Research
Amount of funding: $6m over 5 years
Deadline: LOI: Sept. 5, 2017
Fondation Leduq

National Institute of Health

Integrative Computational Biology for Analysis of NHLBI TOPMed Data (R01)
Deadline: July 6, 2017; July 6, 2018
RFA-HL-18-020

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows POSTDOCS
Deadline: August 8, 2017
PA-16-307

High Risk, High Reward Programs (DP1, DP2, TRA):

  • NIH Director’s Pioneer Award (DP1) $3.5M (Sept. 1) RFA-RM-17-005
  • NIH Director’s New Innovator Award (DP2) $1.5M (Sept. 8) RFA-RM-17-006
  • NIH Transformative Research Award (no budget limit) (Sept. 15) RFA-RM-17-007

NHLBI Program Project Applications (P01) PAR-16-402
Amount of funding: $1,515,000 direct costs per year (5yr max)
Deadline: Sept. 25, 2017
PAR-16-402

NHLBI Bold New Bioengineering Methods and Approaches for Heart, Lung, Blood and Sleep Disorders and Diseases (R21)
Deadline: October 13, 2017; January 10, 2018
RFA-HL-17-015

NHLBI Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01) POSTDOCS
Deadline: October 15, 2017
RFA-HL-16-006

NHLBI Basic Research in Calcific Aortic Valve Disease (R01)
Deadline: October 18, 2017
RFA-HL-18-010